Table 1 FWER, sample size, critical value (CV) and overall power comparisons for 90% marginal power
From: Designs for adding a treatment arm to an ongoing clinical trial
Design | FWER | Total sample size | CV | Overall power |
|---|---|---|---|---|
Two separate trials | 0.0494 | 936 | 1.96 | 0.81 |
Two separate trials: adjustment for multiplicity | 0.0250 | 1104 | 2.24 | 0.81 |
Single trial: no multiplicity adjustment | 0.0454 | 702 | 1.96 | 0.83 |
Single trial: Dunnett adjustment for multiplicity | 0.0250 | 816 | 2.21 | 0.83 |
Adding an arm: no multiplicity adjustment | 0.0477 | 802 | 1.96 | 0.82 |
Adding an arm: Dunnett adjustment for multiplicity | 0.0250 | 922 | 2.23 | 0.82 |