Table 1 Design parameters of the different simulation scenarios. πe0 and πe1 represent the expected control and active event risk, πf1 the maximum tolerable active event risk and r the allocation ratio
Scenario | πe0 (%) | πe1 | πf1 (%) | r | Power (%) |
|---|---|---|---|---|---|
Base-case | 5 | =Ï€e0 | 10 | 1 | 90 |
Alternative 1 | 10 | =Ï€e0 | 15 | 1 | 90 |
Alternative 2 | 5 | \( =\frac{{\boldsymbol{\pi}}_{\boldsymbol{e}\mathbf{0}}}{\mathbf{2}} \) | 10 | 1 | 90 |
Alternative 3 | 5 | =Ï€e0 | 7.5 | 1 | 90 |
Alternative 4 | 5 | =Ï€e0 | 15 | 1 | 90 |
Alternative 5 | 5 | =Ï€e0 | 10 | 0.5 | 90 |
Alternative 6 | 5 | =Ï€e0 | 10 | 2 | 90 |
Alternative 7 | 5 | =Ï€e0 | 10 | 1 | 80 |