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Table 2 List of allowed antibiotic treatments (empirical or targeted)

From: Short postsurgical antibiotic therapy for spinal infections: protocol of prospective, randomized, unblinded, noninferiority trials (SASI trials)

Antibiotic agent

Allowed dosing regimens

Allowed total daily dosea

Levofloxacin by mouth

500 mg every 12 h

750 to 1000 mg

Ciprofloxacin by mouth

500 mg every 12 h

750 to 1500 mg

Amoxicillin/clavulanate by mouth

500/125 mg every 12 h or every 8 h

1000/250 mg to 1500/375 mg

Amoxicillin/clavulanate intravenous

1000/200 mg every 12 h or every 8 h

2000/400 mg to 3000/600 mg

Cefuroxime intravenous

1500 mg every 8 h

4500 mg

Ceftriaxone intravenous

2000 mg every 24 h

2000 mg

Co-trimoxazole by mouth

960 mg every 12 h or every 8 h

1920 to 2880 mg

Clindamycin by mouth

300 or 450 mg every 6 h

1200 to 1800 mg

Doxycycline by mouth

100 mg every 12 h

200 mg

Linezolid by mouth

600 mg every 12 h

1200 mg

Linezolid intravenous

600 mg every 12 h

1200 mg

Metronidazole by mouth

500 mg every 8 h or 500 mg every 6 h

1200 to 2000 mg

Metronidazole intravenous

500 mg every 8 h or every 6 h

1500 to 2000 mg

Vancomycin intravenous

15 mg/kg every 12 h

Target serum levels, 10–20 mg/L

Meropenem intravenous

1 or 2 g every 12 h or every 8 h

2 to 6 g

Piperacillin/tazobactam intravenous

4000/500 mg every 8 h

1200/1500 mg (12 g/1.5 g)

  1. aTo be adapted to renal insufficiency