Completeness and accuracy of national cancer and death registration for outcome ascertainment in trials—an ovarian cancer exemplar

Table 2 National cancer and death registrations versus outcomes review confirmation of tubo-ovarian cancer (a) diagnosis and (b) cause of death

Registry assigned	Outcomes review confirmed (reference standard)				Totals
Registry assigned	Tubo-ovarian^a cancer (ICD-10 C56 /C57.0)	Malignant neoplasm of unknown origin (C80)	No cancer	Other primary cancer	Totals
a. Diagnosis (primary cancer site)
Ovarian/tubal or primary peritoneal cancer (ICD-10 C56 /C57/C48)	1125	33	26	48^b	1232
Malignant neoplasm of unknown origin (C80)	9	91	7	48	155
Benign and ovarian neoplasms of uncertain behaviour (ICD-10 D39.1)	36	0	25	4	65
Other primary cancers	2	2	0	18	22
Total with registry and outcomes review	1172	126	58	118	1474
b. Cause of death
Ovarian/tubal or primary peritoneal cancer (ICD-10 C56 /C57/C48)	605	26	6	19^c	656
Malignant neoplasm of unknown origin (C80)	27	272	10	117	426
Benign and ovarian neoplasms of uncertain behaviour (ICD-10 D39.1)	2	0	4	0	6
Other primary cancer	11	58	2	882	953
Total	645	356	22	1018	2041

^aWHO 2014, includes cancers previously classified as primary peritoneal cancer
^bendometrium 20; leiomyosarcoma broad ligament 4; cervix 1; appendix 3; cecum 1; small bowel 2; bile duct 1; breast 2; colon 5; GI stromal 1; lung 1; NHL 3; pancreas 1; skin 1; small lymphocytic lymphoma 1; vulva 1
^cendometrium (10), colon (3), and one each due to breast cancer, peritoneal mesothelioma, kidney cancer, T cell non-Hodgkin’s lymphoma, lung cancer and oral squamous cell carcinoma

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