1. CHTC uptake (assuming 23% uptake in the standard care arm (arm 3)) | ||||
Proportion (%) of CHTC uptake in arm 1 or arm 2 | 31 | 33 | 35 | 37 |
Corresponding odds ratio (ref = arm 3) | 1.50 | 1.65 | 1.80 | 1.97 |
Power (%) to detect a significant difference among arms at 0.017 significance level with an auto-correlation (rho) = 0.50 | 63 | 84 | 95 | 99 |
Power (%) to detect a significant difference among arms at 0.017 significance level with an auto-correlation (rho) = 0.10 | 87 | 97 | 100 | 100 |
2. HIV-free child survival at 18 months (assuming 91% survival in the standard care arm (arm 3)) | ||||
Proportion (%) of HIV-free survival in arm 1 or arm 2 | 93 | 95 | 97 | 99 |
Corresponding odds ratio (ref = arm 3) | 1.31 | 1.88 | 3.20 | 9.79 |
Power (%) to detect a significant difference among arms at 0.025 significance level | 7 | 26 | 62 | 93 |
3. Maternal viral load suppression at 18 months (assuming viral load suppression of 85% in the standard care arm (arm 3)) | ||||
Proportion (%) of viral load suppression in arm 1 or arm 2 | 90 | 92 | 94 | 96 |
Corresponding odds ratio (ref = arm 3) | 1.59 | 2.03 | 2.77 | 4.24 |
Power (%) to detect a significant difference among arms at 0.025 significance level | 24 | 49 | 77 | 94 |