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Table 1 Hydroxyurea dose adjustment and toxicity criteria

From: Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia

 

Escalation criteria1

Criteria to adjust dose for weight gain2

Toxicity criteria3

Neutrophils

> 3.0 × 109/L

> 1.5 × 109/L

< 0.75 × 109/L

Platelets

> 100 × 109/L

> 120 × 109/L

< 80 × 109/L

Reticulocytes and hemoglobin

ARC> 50 × 109/L if Hb > 7 g/dL

ARC> 100 × 109/L if Hb < 8 g/dL

ARC> 75 if Hb > 8 g/dL

ARC < 50 × 109/L if Hb < 7 g/dL

  1. 1All laboratory criteria must be met to increase the dose
  2. 2All laboratory criteria must be met to adjust the dose. Dose adjustment is recommended when the current dose is ≤ 2.5 mg/kg from the starting dose
  3. 3Toxicity is defined and dose is held if any single one of these laboratory criteria occurs. If toxicity recurs or persists beyond 1 week, dose is decreased
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Trials

ISSN: 1745-6215