Table 3 Participant timeline

Time point

Screening

D0

D1

D2

D3

D4

D5

D28

Number of visits

1

2

3

4

5

6

7

8

Eligibility criteria

x

Informed consent

x

Allocation

x

Demographic data

x

APACHE II

x

SOFA score

x

Laboratory tests (total serum protein, albumin, prealbumin)

x

x

Estimation of energy and protein target

x

Administration of enteral nutrition

x

x

x

x

x

Assessment of tolerance (diarrhea, vomiting, GRV, postpyloric nutrition)

x

x

x

x

x

Assessment of complications

x

x

x

x

x

Assessment of energetic and protein targets

x

x

x

x

x

Assessment of hospital LOS, ICU LOS, and mortality

x