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Table 1 Test evaluation trials

From: Test evaluation trials present different challenges for trial managers compared to intervention trials

Trial title Funder Registration number
BUS - Accuracy of Bladder Ultrasound (BUS) in the diagnosis of Detrusor Overactivity (DO): a study to evaluate if ultrasound can reduce the need for urodynamics [18]. NIHR HTA BUS: ISRCTN:46820623. Registered on September 18, 2012
eGFR-C - Accuracy of glomerular filtration rate (GFR) estimation using creatinine and cystatin C and albuminuria for monitoring disease progression in patients with stage 3 chronic kidney disease [19]. NIHR HTA eGFR-C: ISRCTN: 42955626. Registered on October 08, 2013
ElaTION - The Efficacy and Cost effectiveness of Real Time Ultrasound Elastography in The Investigation Of Thyroid Nodules and the diagnosis of thyroid cancer. NIHR ElaTION: ISRCTN:18261857. Registered on January 28, 2015
ENDCaP-C - Enhanced Neoplasia Detection and Cancer Prevention in Chronic Colitis: a multicentre test accuracy study [20]. NIHR EME ENDCaP-C: ISRCTN:81826545. Registered on May 11, 2015
GBS-2 - Accuracy of a rapid intrapartum test for maternal group B streptococcal colonisation and its potential to reduce antibiotic usage in mothers with risk factors. NIHR GBS-2: ISRCTN:74746075. Registered on April 16, 2015
MEDAL - Can magnetic resonance imaging scan replace or triage the use of laparoscopy in establishing a diagnosis amongst women presenting in secondary care with chronic pelvic pain? [21] NIHR HTA MEDAL: ISRCTN:13028601. Registered on February 20, 2012
IDEA - An observational cohort study to evaluate the clinical utility of current and second-generation interferon-gamma release-assays in diagnostic evaluation of tuberculosis [16, 17]a NIHR HTA IDEA - Not registered
METRIC - Diagnostic accuracy for the extent and activity of newly diagnosed and relapsed Crohn s disease: Multicentre prospective comparison of magnetic resonance imaging and small bowel ultrasound [22]b. NIHR HTA METRIC: ISRCTN:03982913. Registered on November 5, 2013
ROCkeTS – Refining Ovarian Cancer Diagnostic Test Accuracy Scores [23]. NIHR HTA ROCkeTS: ISRCTN:17160843. Registered on June 3, 2015
STREAMLINE-COLON, STREAMLINE-LUNG. Diagnostic accuracy for metastatic disease in newly diagnosed lung and colorectal cancer: Prospective comparison of whole-body magnetic resonance imaging with standard staging pathways-The Streamline Trials [24, 25]c NIHR
HTA
STREAMLINE: ISRCTN:23068310. Registered on August 28, 2015
  1. aManaged by Hilary S Whitworth with input from J Deeks
  2. bManaged by the University College London Clinical Trials Unit, London; senior statistician SM
  3. cManaged by the Cancer Research UK & UCL Cancer Trials Centre, London; senior statistician SM