Table 2 Type 3–5 bleeding criteria according to the BARC classification

Type 3

 Type 3a

 Overt bleeding plus hemoglobin drop of 3 to < 5 g/dL (provided hemoglobin drop is related to bleed)

 Any transfusion with overt bleeding

 Type 3b

 Overt bleeding plus hemoglobin drop ≥ 5 g/dL (provided hemoglobin drop is related to bleed)

 Cardiac tamponade

 Bleeding requiring surgical intervention for control (excluding dental/nasal/skin/hemorrhoid)

 Bleeding requiring intravenous vasoactive agents

 Type 3c

 Intracranial hemorrhage (does not include microbleeds or hemorrhagic transformation, does include intraspinal)

 Subcategories confirmed by autopsy or imaging or lumbar puncture

 Intraocular bleed compromising vision

Type 4: CABG-related bleeding

 Perioperative intracranial bleeding within 48 h

 Reoperation after closure of sternotomy for the purpose of controlling bleeding

 Transfusion of ≥ 5 U whole blood or packed red blood cells within a 48-h period

 Chest tube output ≥ 2 L within a 24-h period

Type 5: fatal bleeding

 Type 5a

 Probable fatal bleeding; no autopsy or imaging confirmation but clinically suspicious

 Type 5b

 Definite fatal bleeding; overt bleeding or autopsy or imaging confirmation