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Fig. 1 | Trials

Fig. 1

From: Downstream or upstream administration of P2Y12 receptor blockers in non-ST elevated acute coronary syndromes: study protocol for a randomized controlled trial

Fig. 1

Study design. Patients are randomly assigned (1:1) to downstream P2Y12 receptor blockers (prasugrel or ticagrelor) or to upstream administration strategy (only ticagrelor). The patients of the downstream arm, who will undergo PCI, will be further randomized (1:1) to downstream prasugrel or downstream ticagrelor before the PCI procedure. All randomizations are blocked by age > 75. Prasugrel is to be administered 60 mg oral bolus then 5 mg daily in subjects > 75 years old or with a weight < 60 kg (**)

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