Assessing the effect of an evidence-based patient online educational tool for people with multiple sclerosis called UMIMS—understanding magnetic resonance imaging in multiple sclerosis: study protocol for a double-blind, randomized controlled trial

Table 1 Major endpoints

Instrument	Measurement time point
	Enrollment	Allocation	Post-allocation
	t₋₁	t₀	t₁	t₂	t₃
Eligibility screen	x				s
Informed consent	x
Allocation	x
Sociodemographic data	x	x
PDDS		x
MS-related data and resource use		x
MRI-RIKNO		x^a	x
Subjective knowledge		x	x
MRI-EMA		x	x	x
CPS		x	x	x
Numeracy		x
Threat by MS		x	x
HADS		x	x
Process evaluation			x	x (patient and physician)	x
MAPPIN’SDM				x (patient and physician)
MAPPIN’SDM audio (n = 5 CG/IG)				x (external rater)
Treatment/MRI decision				x	x

t₁ 2 weeks after allocation and access to the intervention/control website, t₂ immediately after patient-physician encounter, t₃ 6 months after patient-physician encounter, CG control group, CPS Control Preference Scale, HADS Hospital Anxiety and Depression Scale, IG intervention group, MAPPIN’SDM Multifocal Approach to Sharing in Shared Decision Making, MRI-EMA magnetic resonance imaging-emotions and attitude questionnaire, MRI-RIKNO magnetic resonance imaging-risk knowledge questionnaire, PDDS patient-determined disease steps
^aPrimary endpoint

ISSN: 1745-6215