Comparison of peri-implant submucosal microbiota in arches with zirconia or titanium implant-supported fixed complete dental prostheses: a study protocol for a randomized controlled trial

Table 1 Participant timeline

TIMEPOINT	T0	T1	T2	Month0	1 week before Month 6	Month6	1 week before Month 12	Month12	1 week before Month 18	Month18	1 week before Month 24	Month24	1 week before Month 30	Month30	1 week before Month 36	Month36	1 week before Month 42	Month 42	1 week before Month 48	Month 48	1 week before Month 54	Month 54	1 week before Month 60	Month 60
ENROLMENT:
Eligibility screen	X
Informed consent	X
Implant surgery		X
Impression			X
Allocation				X
INTERVENTIONS:
Final restoration: titanium				X
Final restoration: zirconia				X
MAINTANENCES: Ultrasonic debridement with PEEK tips					X		X		X		X		X		X		X		X		X		X
ASSESSMENTS:
Implant survival rate								X								X								X
Peri-implant plaque index				X		X		X		X		X		X		X		X		X		X		X
Bleeding on probing				X		X		X		X		X		X		X		X		X		X		X
Suppuration				X		X		X		X		X		X		X		X		X		X		X
Probing depth				X		X		X		X		X		X		X		X		X		X		X
Mechanical complication						X		X		X		X		X		X		X		X		X		X
Paralleling X-ray				X				X				X				X				X				X
Microbiota sample collection				X		X		X		X		X		X		X		X		X		X		X
Surface roughness				X		X		X		X		X		X		X		X		X		X		X

ISSN: 1745-6215