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Table 2 Immunosuppression protocol after randomization. In the treatment group, patients will receive a reduced dose of everolimus and tacrolimus whereas control patients will receive our standard immunosuppression. MMF will be introduced in both groups 12 months after transplantation

From: Combined low-dose everolimus and low-dose tacrolimus after Alemtuzumab induction therapy: a randomized prospective trial in lung transplantation

Time after LuTx Tacrolimus trough blood level (ng/ml) Everolimus trough blood level (ng/ml) Aprednisolone (mg/kg) MMF
Control Treatment Control Treatment All patients All patients
1–3 months 8–10 4–5 4–5 0.2
3–6 months 6–8 3–4 3–4 0.15
6–12 months 6–8 3–4 3–4 0.1
12–24 months 5–7 2.5 2.5 5 mg/d 1–1.5 g 2× a day