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Table 2 Immunosuppression protocol after randomization. In the treatment group, patients will receive a reduced dose of everolimus and tacrolimus whereas control patients will receive our standard immunosuppression. MMF will be introduced in both groups 12 months after transplantation

From: Combined low-dose everolimus and low-dose tacrolimus after Alemtuzumab induction therapy: a randomized prospective trial in lung transplantation

Time after LuTx

Tacrolimus trough blood level (ng/ml)

Everolimus trough blood level (ng/ml)

Aprednisolone (mg/kg)

MMF

Control

Treatment

Control

Treatment

All patients

All patients

1–3 months

8–10

4–5

–

4–5

0.2

–

3–6 months

6–8

3–4

–

3–4

0.15

–

6–12 months

6–8

3–4

–

3–4

0.1

–

12–24 months

5–7

2.5

–

2.5

5 mg/d

1–1.5 g 2× a day