Table 1 Dosing schedule for study medications
From: A novel human laboratory model for screening medications for alcohol use disorder
Group: | NTX | VAR | PLA | |||
|---|---|---|---|---|---|---|
Day: | AM | PM | AM | PM | AM | PM |
Medication titration | ||||||
1 | 1 capsule (12.5 mg NTX) | 1 capsule (placebo) | 1 capsule (0.5 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) | 1 capsule (placebo) |
2 | 1 capsule (12.5 mg NTX) | 1 capsule (placebo) | 1 capsule (0.5 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) | 1 capsule (placebo) |
3 | 1 capsule (12.5 mg NTX) | 1 capsule (placebo) | 1 capsule (0.5 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) | 1 capsule (placebo) |
4 | 1 capsule (25 mg NTX) | 1 capsule (placebo) | 1 capsule (0.5 mg VAR) | 1 capsule (0.5 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) |
5 | 1 capsule (25 mg NTX) | 1 capsule (placebo) | 1 capsule (0.5 mg VAR) | 1 capsule (0.5 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) |
6 | 1 capsule (25 mg NTX) | 1 capsule (placebo) | 1 capsule (0.5 mg VAR) | 1 capsule (0.5 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) |
7 | 1 capsule (25 mg NTX) | 1 capsule (placebo) | 1 capsule (0.5 mg VAR) | 1 capsule (0.5 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) |
Practice quit attempt | ||||||
8 | 1 capsule (50 mg NTX) | 1 capsule (placebo) | 1 capsule (1 mg VAR) | 1 capsule (1 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) |
9 | 1 capsule (50 mg NTX) | 1 capsule (placebo) | 1 capsule (1 mg VAR) | 1 capsule (1 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) |
10 | 1 capsule (50 mg NTX) | 1 capsule (placebo) | 1 capsule (1 mg VAR) | 1 capsule (1 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) |
11 | 1 capsule (50 mg NTX) | 1 capsule (placebo) | 1 capsule (1 mg VAR) | 1 capsule (1 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) |
12 | 1 capsule (50 mg NTX) | 1 capsule (placebo) | 1 capsule (1 mg VAR) | 1 capsule (1 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) |
13 | 1 capsule (50 mg NTX) | 1 capsule (placebo) | 1 capsule (1 mg VAR) | 1 capsule (1 mg VAR) | 1 capsule (placebo) | 1 capsule (placebo) |
14 | 1 capsule (50 mg NTX) | – | 1 capsule (1 mg VAR) | – | 1 capsule (placebo) | – |