Practicing outcome-based medical care using pragmatic care trials

Table 1 Active care trials integrated into routine care

Care trial	Registration number	Trial concerns	Number of enrolled patients^a	Corresponding publications
CURES	NCT01139892	Surgery or endovascular for unruptured aneurysms	189	[34, 41]
ISAT-2	NCT01668563	Surgery or endovascular for ruptured aneurysms	123	[40, 45]
FIAT	NCT01349582	Flow diversion or best standard care for aneurysms	217	[35, 42]
STAT	NCT01340612	Stent or best standard care for aneurysms	126	[36]
TOBAS	NCT02098252	Arteriovenous malformations (AVMs), treat or not	205	[37, 44]
TOBAS	NCT02098252	Pre-op embolization or not	205	[37, 44]
TATAM	NCT03691870	AVMs, transvenous embolization or best standard care	8	[38]
EASI	NCT02157532	Acute stroke, mechanical thrombectomy or best standard care	320	[33, 46, 47]
RISE	NCT03936647	Intra-saccular flow diverters or best standard care for aneurysms	9	[39]
CAM	NCT04155606	Management of unruptured aneurysms	15	[48]
Total			1212

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