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Table 1 Trial settings and parameters examined in the statistical simulation study

From: Analysis of multicenter clinical trials with very low event rates

Trial design characteristics

Settings

Total sample size

200, 500, 1000, and 5000

Number of centers

5, 50, and 100

ICC

0.025 and 0.075

Control group event probability

0.02, 0.05, and 0.10

Distribution of participants across centers

Balanced and skewed

True odds ratio

1 and > 1

Randomization ratio

1:1

Permuted block size

4