From: Analysis of multicenter clinical trials with very low event rates
Trial design characteristics | Settings |
---|---|
Total sample size | 200, 500, 1000, and 5000 |
Number of centers | 5, 50, and 100 |
ICC | 0.025 and 0.075 |
Control group event probability | 0.02, 0.05, and 0.10 |
Distribution of participants across centers | Balanced and skewed |
True odds ratio | 1 and > 1 |
Randomization ratio | 1:1 |
Permuted block size | 4 |