TY - JOUR AU - Manrique-Saide, Pablo AU - Dean, Natalie E. AU - Halloran, M. Elizabeth AU - Longini, Ira M. AU - Collins, Matthew H. AU - Waller, Lance A. AU - Gomez-Dantes, Hector AU - Lenhart, Audrey AU - Hladish, Thomas J. AU - Che-Mendoza, Azael AU - Kirstein, Oscar D. AU - Romer, Yamila AU - Correa-Morales, Fabian AU - Palacio-Vargas, Jorge AU - Mendez-Vales, Rosa AU - Pérez, Pilar Granja AU - Pavia-Ruz, Norma AU - Ayora-Talavera, Guadalupe AU - Vazquez-Prokopec, Gonzalo M. PY - 2020 DA - 2020/10/08 TI - The TIRS trial: protocol for a cluster randomized controlled trial assessing the efficacy of preventive targeted indoor residual spraying to reduce Aedes-borne viral illnesses in Merida, Mexico JO - Trials SP - 839 VL - 21 IS - 1 AB - Current urban vector control strategies have failed to contain dengue epidemics and to prevent the global expansion of Aedes-borne viruses (ABVs: dengue, chikungunya, Zika). Part of the challenge in sustaining effective ABV control emerges from the paucity of evidence regarding the epidemiological impact of any Aedes control method. A strategy for which there is limited epidemiological evidence is targeted indoor residual spraying (TIRS). TIRS is a modification of classic malaria indoor residual spraying that accounts for Aedes aegypti resting behavior by applying residual insecticides on exposed lower sections of walls (< 1.5 m), under furniture, and on dark surfaces. SN - 1745-6215 UR - https://doi.org/10.1186/s13063-020-04780-7 DO - 10.1186/s13063-020-04780-7 ID - Manrique-Saide2020 ER -