Combined HIV Adolescent Prevention Study (CHAPS): comparison of HIV pre-exposure prophylaxis regimens for adolescents in sub-Saharan Africa—study protocol for a mixed-methods study including a randomised controlled trial

Table 4 Sample collection and sample analysis

Specimen type	Volume/amount of sample	Analysis
Safety blood	4 ml EDTA	Haemoglobin
Safety blood	5 ml SSAT	HIV
Research blood	51 ml ACD	Ex vivo challenge, drug levels, cytokines
Rectal swab	1 swab	Drug levels
Urethral swab	1 swab	Inflammation
Coronal sulcus swab	1 swab	Microbiome
Foreskin	Circumcised foreskin	Ex vivo challenge, drug levels, inflammation and microbiome
Urine	5 ml	Drug level
Urine	5 ml	STI screen

ISSN: 1745-6215