Hypofractionated radiation therapy comparing a standard radiotherapy schedule (over 3 weeks) with a novel 1-week schedule in adjuvant breast cancer: an open-label randomized controlled study (HYPORT-Adjuvant)—study protocol for a multicentre, randomized phase III trial

Table 2 The dose constraints to be used for plan evaluation

Volume	Standard arm			Test arm
Volume	Criteria	Mandatory	Optimal	Criteria	Mandatory	Optimal
BTV (only in patients receiving SIB)	D98	≥ 43.2 Gy	NA	D98	≥ 28.8 Gy	NA
	D95	≥ 45.6 Gy	NA	D95	≥ 30.4 Gy	NA
	D2	≤ 51.4 Gy	≤ 50.4 Gy	D2	≤ 34.2 Gy	≤ 33.6 Gy
	D0.03	≤ 52.8 Gy	≤ 51.4 Gy	D0.03	≤ 35.2 Gy	≤ 34.2 Gy
Heart	Mean	≤ 2.5 Gy	≤ 2 Gy	Mean	≤ 1.6 Gy	≤ 1.3 Gy
	V10	≤ 5%	≤ 3%	V7	≤ 5%	≤ 3%
	V2	≤ 30%	≤ 20%	V1.2	≤ 30%	≤ 20%
Ipsilateral lung	V12	≤ 30%	≤ 18%	V8	≤ 30%	≤ 18%

ISSN: 1745-6215