Related to | Classification | Symptom | Definition | CTCAE grade and definition |
---|---|---|---|---|
RAI | Local | Neck pain | A disorder characterized by marked discomfort sensation in the neck area | Grade 2 (impairment of instrumental activities of daily living) and above |
RAI | Local | Neck swelling | A disorder characterized by marked enlargement in the neck area | Grade 2 (impairment of instrumental ADL) and above |
RAI | Local | Dysphagia | A disorder characterized by difficulty in swallowing | Grade 2 (symptomatic and altered eating/swallowing) and above |
RAI | Local | Dyspnoea | A disorder characterized by difficulty in breathing | Any grade |
RAI | Oral | Sialadenitis | A disorder characterized by an inflammatory process involving the salivary gland | Grade 2 (moderate symptoms; oral intervention indicated) and above |
RAI | Oral | Dry mouth | A disorder characterized by reduced salivary flow in the oral cavity | Grade 2 (moderate symptoms; oral intake alterations; unstimulated saliva 0.1 to 0.2 mL/min) |
RAI | Oral | Oral mucositis | A disorder characterized by inflammation of the oral mucosal | Grade 2 (moderate pain; not interfering with oral intake; modified diet indicated) and above |
RAI | Oral | Oral pain | A disorder characterized by a sensation of marked discomfort in the mouth, tongue or lip | Grade 2 (moderate pain; limiting instrumental ADL) and above |
RAI | Oral | Dysgeusia | A disorder characterized by abnormal sensual experience with the taste of foodstuffs | Grade 2 (altered taste with change in diet (e.g. oral supplements), noxious or unpleasant taste, loss of taste) and above |
RAI | Gastrointestinal | Nausea | A disorder characterized by a queasy sensation and/or the urge to vomit | Grade 2 (oral intake decreased without significant weight loss, dehydration or malnutrition) and above |
RAI | Gastrointestinal | Vomiting | A disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth | Grade 2 (3–5 episodes (separated by 5 min) in 24 h) and above |
RAI/glucocorticoids | Gastrointestinal | Dyspepsia | A disorder characterized by an uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach, bloating, heartburn, nausea and vomiting | Grade 2 (moderate symptoms; medical intervention indicated) or above |
RAI/glucocorticoids | Gastrointestinal | Abdominal pain | A disorder characterized by a sensation of marked discomfort in the abdominal region | Grade 2 (moderate pain; limiting instrumental ADL) |
RAI | Eye | Xerophthalmia | A disorder characterized by dryness of the cornea and conjunctiva | Grade 2 (symptomatic; multiple agents indicated; limiting instrumental ADL) and above |
RAI | Eye | Epiphoria | A disorder of excessive tearing in the eyes | Grade 2 (intervention indicated) and above |
RAI | Eye | Conjunctivitis | A disorder characterized by inflammation, to the conjunctiva of the eye | Grade 2 (symptomatic; topical intervention indicated (e.g. antibiotics); limiting instrumental ADL) and above |
Glucocorticoids | General | Infections within 2 weeks | A disorder characterized by an infectious process | Grade 2 (any infection that needs intervention) or above |
Glucocorticoids | General | Hyperglycaemia during the first 3 days | A disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar | Grade 3 (> 250–500 mg/dL; > 13.9–27.8 mmol/L; hospitalization indicated) or above |
Glucocorticoids | Central nervous system | Altered sensorium | A disorder characterized by functional disturbances of sensory neurons resulting in abnormal cutaneous sensations of tingling, numbness, pressure, cold and warmth that are experienced in the absence of a stimulus | Grade 2 (moderate symptoms limiting instrumental ADL) and above |
Glucocorticoids | Central nervous system | Sleep disturbances | A disorder characterized by excessive or reduced sleepiness or difference in sleep pattern | Grade 2 (moderate disturbance) or above |
Glucocorticoids | Central nervous system | Mood changes | A disorder characterized by a state of restlessness, irritability or sadness | Grade 3 (moderate symptoms; hospitalization not indicated) or above |