Table 1 Visit overview

Week

− 1

0

16 ± 2

3 (− 1/+ 2) weeks after Chemotherapy

48 ± 2

96 ± 2

144 ± 2

 Eligibility screen

X

 Informed consent

X

 Randomization

X

 Allocation

X

 Intermittent fasting

 Plant-based, sugar-restricted diet

 Nutritional counseling

X

 Demographic data

X

 Medical history

X

 Concomitant medication

X

X

X

X

X

X

 Anthropometric measurements

X

X

X

X

X

X

 Vital signs (blood pressure, heart rate)

X

X

X

X

X

X

 Bioelectrical impedance analysis

X

X

X

X

X

X

 Physical examination

X

X

X

X

X

X

 AE/SAE query

X

X

X

X

X

 Blood panel

 Blood values for liver and renal function

 IGF-1, insulin, glucose, and ketone bodies in blood samples of subgroup^b

 IGF-1, insulin^b

 Ketone bodies^b

X

X

X

X

 Long-term explorative measurements: e.g., polyneuropathy, cardiomyopathy Frequency of recurrence

X

X

X

X

X

X

 CTCAE

X

X

X

X

X

 FACT-G

X

X

X

X

X

X

 TOI (= PWB+FWB+AC)

X

X

X

X

X

X

 Total AC (FACT-B/FACT-O)

X

X

X

X

X

X

 FACIT-F

X

X

X

X

X

X

 FACT-Tax,FACT/GOG-Ntx

X

X

X

X

X

X

 CIPNAT

X

X

X

X

X

X

 HADS

X

X

X

X

X

X

 Side effects of chemotherapy

X

X

X

X

X

X

 Qualitative interviews in focus groups

X

X