Table 1 Procedures and measures administered at each study visit

Informed Consent: Initial Screen

x

Informed Consent: Experimental/Medical

x

Adverse Childhood Experience Questionnaire (ACE)

x

Adverse Events/Serious Adverse Events (AE/SAE)

x

x

x

x

x

Alcohol Breathalyzer

x

x

x

x

x

x

Alcohol Dependency Scale (ADS)

x

x

x

x

Alcohol Purchase Task (APT)

x

x

x

x

Alcohol Use Disorders Identification Test (AUDIT)

x

Beck Anxiety Inventory (BAI)

x

x

x

x

x

Beck Depression Inventory-Revised (BDI-II)

x

x

x

x

x

Birth Control Assessment

x

Brain Imaging (if eligible)

x

Brief Trauma Questionnaire (BTQ)

x

Clinical Institute W/D Assessment for Alcohol (CIWA-AR)

x

x

x

x

x

Columbia Suicide Severity Rating Scale (C-SSRS)

x

x

x

x

x

Safety Labs CMP/CBC (blood sample)

x

x

Concomitant Medications

x

x

x

x

x

x

Cannabis Use Disorder Identification Test (CUDIT)

x

Demographics

x

Drinking Goal

x

Drug Compliance/Accountability

x

x

x

Drug Screen (urine sample)

x

x

x

x

x

x

Electrocardiogram (ECG)

x

x

Fagerstrom Test for Nicotine Dependence (FTND)

x

Family Tree Questionnaire (FTQ)

x

Graded Chronic Pain Scale (GCPS)

x

x

x

x

ImBIBe

x

x

x

x

x

Inflammation and Behavior Questionnaire

x

x

x

x

Insomnia Severity Index (ISI)

x

x

x

x

x

Locator Form

x

Medical History

x

NIH Toolbox

x

x

Neuroimmune assays (blood sample)

x

x

x

x

Penn Alcohol Craving Scale (PACS)

x

x

x

x

x

Physical Exam

x

Pregnancy Test (urine sample)

x

x

x

x

x

Profile of Mood States (POMS)

x

x

x

x

x

Readiness to Change (RTC) Ladder

x

Reward-Relief Drinking Scale

x

Risky Families Questionnaire

x

Salivary Cortisol Testing

x

Spielberger State-Trait Anxiety Scale (STAI)

x

Structured Clinical Interview for DSM-5 (SCID-5)

x

Subjective Distress Units Scale (SUDS)

x

Take Control (Computer-delivered)

x

x

x

x

Timeline Follow Back (TLFB)

x

x

x

x

x

x

x

Vital Signs (including weight)

x

x

x

x

x

x

x