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Table 2 Expected power for different event rates. The statistical power of the DOSE-AGE trial with 784 participants based on different assumptions for the true probability of moderate-to-severe gastroenteritis in 7 days following enrollment, as measured by the Modified Vesikari Scale score

From: A pragmatic randomized controlled trial of multi-dose oral ondansetron for pediatric gastroenteritis (the DOSE-AGE study): statistical analysis plan

Event rate for placebo control

Event rate for multi-dose ondansetron

Absolute risk reduction with multi-dose ondansetron

Statistical power to detect difference

0.25

0.15

0.10

0.94

0.25

0.2

0.05

0.39

0.25

0.25

0.0

NA

0.3

0.15

0.15

0.999

0.3

0.25

0.05

0.35

0.35

0.15

0.2

~ 1

0.35

0.2

0.15

0.997

0.35

0.25

0.1

0.87