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Table 1 Intermittent feeding protocol (experimental group)

From: Protein delivery in intermittent and continuous enteral nutrition with a protein-rich formula in critically ill patients—a protocol for the prospective randomized controlled proof-of-concept Protein Bolus Nutrition (Pro BoNo) study

Time

06:00–06:30

 

10:30

11:00–11:30

 

15:30

16:00–16:30

 

20:30

21:00–21:30

 

01:30

 

Nutrition

Break

GRV

Nutrition

Break

GRV

Nutrition

Break

GRV

Nutrition

Break

GRV

Break

Day 1

Protein dose1

0.1

  

0.2

  

0.4

  

0.4

   

Flow rate2

50–90

  

100–180

  

200–360

  

200–360

   

Total protein3

0.1

0.3

0.7

1.1

Day 2

Protein dose1

0.4

  

0.4

  

0.4

  

0.4

   

Flow rate2

200–360

  

200–360

  

200–360

  

200–360

   

Total protein3

1.4

1.6

1.6

1.6

  1. GRV gastric residual volume
  2. 1[g/kgBW/30 min], 4 nutrition cycles/24 h: each with 30 min nutrition followed by a 4-h break and 30 min GRV measure, night time break of 4 h. Total time of feeding, 2 h; GRV measurements, 2 h; break, 20 h
  3. 2[ml Fresubin© Intensive/30 min], depending on bodyweight
  4. 3Total of administered protein of the preceding 24 h [g/kgBW]
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Trials

ISSN: 1745-6215