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Table 2 Four embedded adaptive interventions in the proposed SMART trial study

From: Adaptive interventions for optimizing malaria control: an implementation study protocol for a block-cluster randomized, sequential multiple assignment trial

Embedded adaptive intervention

First-stage intervention

Status at end of first-stage treatment

Second-stage intervention option

Subgroup in the design

#1

PBO LLIN

Responder

Continue PBO LLIN

B + C

Non-responder

PBO LLIN + LSM

#2

PBO LLIN

Responder

Continue PBO LLIN

B + D

Non-responder

Enhanced machine learning method

#3

LLIN + IRS

Responder

Continue IRS

E + F

Non-responder

LLIN + IRS + LSM

#4

LLIN + IRS

Responder

Continue IRS

E + G

Non-responder

PBO LLIN + IRS