Embedded adaptive intervention | First-stage intervention | Status at end of first-stage treatment | Second-stage intervention option | Subgroup in the design |
---|---|---|---|---|
#1 | PBO LLIN | Responder | Continue PBO LLIN | B + C |
Non-responder | PBO LLIN + LSM | |||
#2 | PBO LLIN | Responder | Continue PBO LLIN | B + D |
Non-responder | Enhanced machine learning method | |||
#3 | LLIN + IRS | Responder | Continue IRS | E + F |
Non-responder | LLIN + IRS + LSM | |||
#4 | LLIN + IRS | Responder | Continue IRS | E + G |
Non-responder | PBO LLIN + IRS |