A narrative review of estimands in drug development and regulatory evaluation: old wine in new barrels?

Table 1 Frequency of attribute presence/description in guidelines, sponsor documentations and regulatory questions

	Frequency of attribute presence
Source document	Guidelines (N = 34) (%)	Sponsor documentations (N = 34) (%)	Regulatory questions (N = 34^*) (%)
Attribute	Guidelines (N = 34) (%)	Sponsor documentations (N = 34) (%)	Regulatory questions (N = 34^*) (%)
Variable	100	100	68
Population	24	100	3
Population-level summary	38	100	3
Intercurrent events	79	100	68
Strategies intercurrent events	53	100	44

ISSN: 1745-6215