Fig. 3

SPIRIT figure Abbreviations: MR CLEAN-MED, Multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke. The effect of periprocedural medication: acetylsalicylic acid, unfractionated heparin, both or neither; ASA, intravenous acetylsalicylic acid; UFH, intravenous unfractionated heparin; DSA, digital subtraction angiography; NCCT, non-contract computed tomography; CTA, computed tomography angiography; MRI, magnetic resonance imaging; MRA, magnetic resonance angiography; NIHSS, National Institutes of Health Stroke Scale; (s)ICH, symptomatic intracranial hemorrhage; mRS, modified Rankin Scale.Captions: *See trial protocol on https://www.mrclean-med.nl for more information about the patient flow, enrollment, interventions, and assessments; **t₁ = within 1 hour before groin puncture, after randomization; t₂ = after groin puncture/during EVT; t₃ = after EVT; t₄ = 24 hours after EVT; t₅ = 5-7 days after EVT or at discharge; t₆ = 90 days after EVT; ***Informed consent: as early as deemed possible after EVT; ****ASA/UFA loading dose administered directly after groin puncture, or prior to groin puncture in case no recombinant tissue plasminogen activator has been given, UFH continuous infusion until 6 hours after EVT; *****Blood samples: within 1 hour before groin puncture, within 1 hour after EVT, at 24 hours after EVT, if applicable 2-6 months after EVT; ******Recanalization grade on DSA at t₂, and CTA or MRA at t₄