Table 2 Treatments and dosing schedule
Medication | Licensed dose range in the elderly | Notes from the registered summary of product characteristics |
|---|---|---|
Vortioxetine | 5–20 mg/day | The minimum effective dose of 5 mg vortioxetine once daily should always be used as an initial dose for participants aged ≥ 65 years. Caution should be exerted when prescribing to elderly participants at doses > 10 mg vortioxetine once daily |
Sertraline | 50–200 mg/day | Caution is required in the elderly, because these patients may be at greater risk of hyponatraemia |
Paroxetine | 20–40 mg/day | In the elderly, increased plasma concentrations of paroxetine have been reported, however, within the range observed in younger patients. The treatment should start at the same doses used in adults |
Citalopram | 10–20 mg/day | In the elderly, half of the dose range prescribed in adults is required |
Escitalopram | 5–10 mg/day | In the elderly, half of the dose range prescribed in adults is required |
Fluoxetine | 20–60 mg/day | Caution is required when the dose is increased in the elderly, and generally the daily dose should not be above 40 mg/day. The maximum recommended dose is 60 mg/day |
Fluvoxamine | 100–300 mg/day | In elderly participants, titration should be slower and the dosage should always be established with caution |