Skip to main content

Table 1 Scheduled assessments

From: Chinese herbal medicine combined with entecavir to reduce the off-therapy recurrence risk in HBeAg-positive chronic hepatitis B patients: a multi-center, double-blind, randomized controlled trial in China

Assessment

Consolidation therapy

Off-therapy observation

Treatment after recurrence

Day 1

12 w

24 w

36 w

48 w

60 w

72 w

84 w

96 w

4 w

8 w

12 w

16 w

20 w

24 w

Recurrence

Blood, urinary, and stool routine test

 

 

 

 

     

 

Liver functions

 

 

 

 

Renal function

 

 

 

 

     

 

HBV-serum marker

 

 

 

 

  

  

HBV DNA

 

 

 

 

Liver biopsy

       

       

ccc DNA

       

       

HBcrAg

 

 

 

 

  

  

 

HBV pregenomic RNA

 

 

 

 

  

  

 

LHBs

 

 

 

 

  

  

 

AFP

 

 

 

 

     

 

PT

         

 

ECG

 

 

 

 

     

 

Abdominal ultrasound scan

 

 

 

 

     

 

Antibodies of hepatitis A, C, D, E

               

CLDQ

  

  

 

SF-36

  

  

 

The symptom score of TCM

  

  

 
  1. Patients will be followed up every 12 weeks during the consolidation therapy and every 4 weeks in the off-therapy observation (“w” is short for “weeks”)
  2. Abbreviations: HBV hepatitis B virus, ccc DNA covalently closed circular DNA, HBcrAg hepatitis B core-related antigen, LHBs HBV large surface proteins, AFP alpha fetoprotein, PT prothrombin time, ECG electrocardiogram, SF-36 the Short Form (36-item) Health Survey, CLDQ the Chronic Liver Disease Questionnaire