Assessment | Consolidation therapy | Off-therapy observation | Treatment after recurrence | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Day 1 | 12 w | 24 w | 36 w | 48 w | 60 w | 72 w | 84 w | 96 w | 4 w | 8 w | 12 w | 16 w | 20 w | 24 w | Recurrence | |
Blood, urinary, and stool routine test | √ | √ | √ | √ | √ | √ | ||||||||||
Liver functions | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ | ||||
Renal function | √ | √ | √ | √ | √ | √ | ||||||||||
HBV-serum marker | √ | √ | √ | √ | √ | √ | √ | √ | ||||||||
HBV DNA | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ | ||||
Liver biopsy | √ | √ | ||||||||||||||
ccc DNA | √ | √ | ||||||||||||||
HBcrAg | √ | √ | √ | √ | √ | √ | √ | |||||||||
HBV pregenomic RNA | √ | √ | √ | √ | √ | √ | √ | |||||||||
LHBs | √ | √ | √ | √ | √ | √ | √ | |||||||||
AFP | √ | √ | √ | √ | √ | √ | ||||||||||
PT | √ | √ | √ | √ | √ | √ | ||||||||||
ECG | √ | √ | √ | √ | √ | √ | ||||||||||
Abdominal ultrasound scan | √ | √ | √ | √ | √ | √ | ||||||||||
Antibodies of hepatitis A, C, D, E | √ | |||||||||||||||
CLDQ | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ | |||||
SF-36 | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ | |||||
The symptom score of TCM | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ | √ |