Table 1 Schedule of enrollment, interventions, and outcome assessment
| Action/timepoint | Enrollment |
Baseline survey (M 0) | Randomization | Treatment | Follow-up (M 7) | Follow-up (M 12) | Follow-up (M 24) |
|---|---|---|---|---|---|---|---|
| Informed consent | ⚪ | ||||||
| Demographic characteristics | ⚪ | ||||||
| Medical history | ⚪ | ||||||
| Physical examination | ⚪ | ||||||
| Questionnaire (OSA-20) | ⚪ | ||||||
| Lateral cephalometrics | ⚪ | ⚪ | ⚪ | ⚪ | |||
| Polysomnogram | ⚪ | ⚪ | ⚪ | ⚪ | |||
| Confirm suitability for study | ⚪ | ||||||
| Allocation | ⚪ | ||||||
| Drug treatment | ⚪ | ||||||
| Surgical treatment | ⚪ | ||||||
| Orthodontic treatment | ⚪ | ||||||
| Surgery and postoperative orthodontic treatment | ⚪ | ||||||
| Assessment | |||||||
| Symptom changes | ⚪ | ⚪ | ⚪ | ||||
| Questionnaire (OSA-20) | ⚪ | ⚪ | ⚪ | ⚪ | |||
| Cephalometric measurements | ⚪ | ⚪ | ⚪ | ⚪ | |||
| Morphologic analysis of UA | ⚪ | ⚪ | ⚪ | ⚪ | |||
| Polysomnogram | ⚪ | ⚪ | ⚪ | ⚪ | |||
| Safety assessment | ⚪ | ⚪ | ⚪ | ||||