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Table 1 Main components of YinQiSanHuang-antiviral decoction

From: Efficacy and safety of YinQiSanHuang-antiviral decoction in chronic hepatitis B: study protocol for a randomized, placebo-controlled, double-blinded trial

Chinese nameLatin nameEnglish namePharmacological actionMain active ingredientOriginal producing areaMedicinal partDosage (g)
Huang QiAstragalus propinquus SchischkinRadix AstragaliPromotes liver cell growth, anti-liver fibrosis, antiviral, regulates immunityAstragaloside (I,V, III), calycosinNeimenggu, ChinaRhizome12
Yin ChenArtemisia capillaris Thunb.Virgate wormwood herb, capillary wormwood herbLowers blood lipids to treat fatty liver, reduces alcoholic liver damage, inhibits the replication of hepatitis B virus DNACapillin, capillene, capillanol, capillarisin, 6, 7-dimethylsculetinShanxi, ChinaAboveground part of the plant12
Huang QinScutellaria baicalensis GeorgiBaical skullcap rootAnti-hepatocyte inflammation, anti-hepatocyte apoptosis, anti-hepatocyte mitochondrial lipid peroxidation, regulates immunityBaicalein, neobaicalein, skullcap flavone II, baicalin, wogoninHebei, ChinaRhizome3
Huang LianCoptis chinensis Franch.Coptis rootAnti-hepatocyte mitochondrial lipid peroxidation, inhibits hepatoma cell proliferation, prevents liver fibrosisBerberine, coptisine, epiberberine, berberrubine, palmatineSichuan, ChinaTuber root3
Huang BaiPlatycladus orientalis (Linn.) FrancoBark of Chinese corktreeInhibits immune response, selectively inhibits HBAg, anti-inflammatoryBerberine, phellodendrine, magnoflorine, jatrorrhizine, palmatineSichuan, ChinaDry bark3
E ZhuCurcuma aeruginosa Roxb. [C. zedoaria Rosc.]Rhizome curcumaeInhibits hepatoma cell proliferation, induces apoptosis of liver cancer cells, anti-liver fibrosisVolatile oil (turmerone, borneol, curcumol), curcumene, curdione, turmericGuangxi, ChinaTuber root6
Bie JiaTrionyx sinensis (Wiegmann)Turtle shellAnti-liver fibrosis, promotes immunity, anti-hepatocyte injuryCollagen, Trionyx sinesis polysaccharides, amino acids (aspartic acid, threonine, glutamic acid), calcium carbonate, calcium phosphateHubei, ChinaCarapace3
Jiao Shan ZhaCrataegus pinnatifida Bunge var. major N.E. Br.Hawthorn fruitLowers cholesterol, anti-bacterial, anti-hypertensiveEpicatechin, quercetin, hyperoside, chlorogenic acid, anthocyanin, ursolic acidShandong, ChinaFruit15
Bai ShaoPaeonia lactiflora Pall.Radix paeoniae albaAnti-hepatocyte injury, anti-liver fibrosis, anti-fatty liverPaeoniflorin, oxy-paeoniflorin, benzoylpaeoniflorin, albiflorin, paeoniflorigenoneAnhui, ChinaRhizome12
Ling Xiao HuaCampsis grandiflora (Thunb.) K. Schum.Trumpet creeper flowerAnti-oxidation, inhibits thrombosis, anti-inflammatoryApigenin, β-sitosterolJiangsu, ChinaFlower6
Bai ZhuAtractylodes macrocephala Koidz.Largehead atractylodes rhizomeInhibits liver cancer cell metastasis, promotes cellular immune function, inhibits the activating of metabolic enzymesVolatile oil (humulene, β-elemol, α-curcumene, α-atractylone, 3β-acetoxyatractylone), sesquiterpene lactone compounds (atractylenolide, 8β-ethoxyatractylenolide-II), polyacetylene(14-acetyl-12-senecioyl-2E,8Z,10E-atracetylentriol)Zhejiang, ChinaTuber root9
Fu LingPoria cocos (Schw.) Wolf.TuckahoeEnhances cellular and humoral immunity, inhibits the DNA synthesis of tumor cells, inhibits hepatocyte necrosis, anti-tumorPachymic acid, tumulosic acid, pachymic acid methyl ester, pachy-man, pachymaranYunnan, ChinaDry sclerotia9
Chai HuBupleurum chinense DC.Red thorowax rootAnti-liver fibrosis, inhibits acute liver injury, inhibits proliferation of liver cancer cells, promotes apoptosis of liver cancer cells, anti-liver injuryVolatile oil (pentanoic acid, hexanoic acid, heptanoic acid, 2-heptenoic acid)Hebei, ChinaRhizome6
Bai Hua She She CaoHedyotis diffusa Willd.Spreading hedyotis herbEnhances hepatocyte immunogenicity, anti-tumor, inhibits proliferation of liver cancer cells, promotes apoptosis of liver cancer cellsAsperuloside, asperulosidic acid, deacetylasperulosidicacid, geniposidic acid, scandosideGuangxi, ChinaWhole plant12