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Table 1 Timeline of the study and clinical data collection

From: Less invasive surfactant administration versus endotracheal surfactant instillation followed by limited peak pressure ventilation in preterm infants with respiratory distress syndrome in China: study protocol for a randomized controlled trial

Birth to 00Surfactant administration (-10min-+10min)72 hours after birthAt 36 weeks PMA or at discharge
Eligibility screenX    
Informed consentX    
Allocation X   
Primary outcomes
 1.Need for ventilation during the first 72 hours
 2. Mortality
 3. BPD
Secondary outcomes
Need for and the duration of MV (days), duration (days) of non-invasive respiratory support, severe co-morbidities, pneumothorax, massive pulmonary hemorrhage within 48 h of surfactant administration, hemodynamically significant patent ductus arteriosus that needs medical or surgical intervention,
Duration of hospitalization,
Failure rate of LISA or LPPSA
  1. LPPSA surfactant administration followed by low peak pressure, LISA less invasive surfactant administration