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Table 4 Adverse events

From: Comparing the effectiveness of magnesium oxide and naldemedine in preventing opioid-induced constipation: a proof of concept, single institutional, two arm, open-label, phase II, randomized controlled trial: the MAGNET study

Grade 1 (mild)Asymptomatic or mild symptoms, clinical or diagnostic observations only, intervention not indicated
Grade 2 (moderate)Minimal, local, or noninvasive intervention indicated, limiting age-appropriate instrumental ADL
Grade 3 (severe)Medically significant but not immediately life-threatening, hospitalization or prolongation of hospitalization indicated, disabling, limiting self-care ADL
Grade 4 (life-threatening)Life-threatening consequences, urgent intervention indicated
Grade 5 (death)Death related to AE
  1. ADL Activities of daily living, AE Adverse events