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Table 4 Adverse events

From: Comparing the effectiveness of magnesium oxide and naldemedine in preventing opioid-induced constipation: a proof of concept, single institutional, two arm, open-label, phase II, randomized controlled trial: the MAGNET study

Grade

Description

Grade 1 (mild)

Asymptomatic or mild symptoms, clinical or diagnostic observations only, intervention not indicated

Grade 2 (moderate)

Minimal, local, or noninvasive intervention indicated, limiting age-appropriate instrumental ADL

Grade 3 (severe)

Medically significant but not immediately life-threatening, hospitalization or prolongation of hospitalization indicated, disabling, limiting self-care ADL

Grade 4 (life-threatening)

Life-threatening consequences, urgent intervention indicated

Grade 5 (death)

Death related to AE

  1. ADL Activities of daily living, AE Adverse events