Table 2 Analysis configurations arising from three decision categories

Choice of endpoint

1. Coronary heart disease (CHD) death^a

2. Revascularisation

3. All-cause mortality

Analysis set composition

1. No exclusions (i.e. all randomised patients)^a

2. Exclude patients with eGFR < 45 (Stage 3a kidney disease or worse) (excludes 4%)

3. Exclude patients with qualifying events within 9 months of randomisation (excludes 29%)

Covariate specification

1. None^a

2. Stroke (2 levels: yes, no)

3. Smoking status (2 levels: never smoked, current/ex-smoker)

4. Index ACS (3 levels: unstable angina pectoris (UAP), single myocardial infarction (MI), multiple MI)

5. Stroke and smoke

6. Stroke and index ACS

7. Smoke and index ACS

8. Stroke, smoke and index ACS