Study Protocol for Better Evidence for Selecting Transplant Fluids (BEST-Fluids): a pragmatic, registry-based, multi-center, double-blind, randomized controlled trial evaluating the effect of intravenous fluid therapy with Plasma-Lyte 148 versus 0.9% saline on delayed graft function in deceased donor kidney transplantation

Table 1 Physicochemical characteristics of selected electrolyte solutions and human plasma

	0.9% Saline	Ringers Lactate	Plasmalyte	Human plasma
Sodium (mmol/L)	154	130	140	136–145
Potassium (mmol/L)	0	4	5	3.5–5.0
Magnesium (mmol/L)	0	0	1.5	0.8–1.0
Calcium (mmol/L)	0	2.7	0	2.2–2.6
Chloride (mmol/L)	154	109	98	98–106
Acetate (mmol/L)	0	0	27	0
Gluconate (mmol/L)	0	0	23	0
Lactate (mmol/L)	0	28	0	0
pH	6.8	6.5	7.4	7.35–7.45
Osmolarity (mOsm/L)	308	273	295	280–296
Calculated osmolality in vivo^a (mOsm/kg)	287	254	271
Isotonic with plasma	Yes	No^b	Yes

^aSodium and chloride are only partially osmotically active with an osmotic coefficient of 0.926
^bRingers Lactate is hypotonic compared with plasma

ISSN: 1745-6215