Fig. 1
From: Analysis of responder-based endpoints: improving power through utilising continuous components
Illustration of how (hypothetical) response information from patients is weighted by the two different methods. Non-responders consist of those in whom the continuous component is below 1 and those who do not respond according to another binary criterion. Underlying the augmented binary method is a joint model that is fitted to the continuous and binary data and yields fitted ‘response weights’ for each patient; these can then be compared between arms