The design and statistical aspects of VIETNARMS: a strategic post-licensing trial of multiple oral direct-acting antiviral hepatitis C treatment strategies in Vietnam

Table 2 Priors to be used in final analysis

	Primary analysis: uninformative	Sensitivity analyses
	Primary analysis: uninformative	Sceptical	Enthusiastic
Control cure rate	Beta(4.75, 0.25)	Beta(4.75, 0.25)	Beta(4.75, 0.25)
Regimen comparison	N(0, 10,000)	N(−0.05, 0.009)	N(0, 0.009)
Strategy comparison	N(0, 10,000)	N(−0.1, 0.0036)	N(0, 0.0036)
Ribavirin comparison	N(0, 10,000)	N(0, 0.009)	N(0.05, 0.009)

The beta prior for the control cure rate has mean 0.95 and variance 0.008
The model will also be adjusted for genotype, which will have the prior N (0, 10,000) in all analyses
N(m,v) is the normal prior with mean m and variance v

ISSN: 1745-6215