Table 4 Stopping boundaries
Interim analysis | Number of primary outcome events (information fraction) | Stopping boundaries | |||
|---|---|---|---|---|---|
Superiority | Futility | ||||
Hazard ratio | P-value | Hazard ratio | P-value | ||
1 | 800 (50%) | < 0.768 | < 0.0002 | > 0.979 | > 0.758 |
2 | 1200 (75%) | < 0.806 | < 0.0002 | > 0.931 | > 0.216 |
Final | 1600 (100%) | < 0.906 | < 0.0500 |  |  |