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Table 4 Stopping boundaries

From: The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design

Interim analysisNumber of primary outcome events (information fraction)Stopping boundaries
SuperiorityFutility
Hazard ratioP-valueHazard ratioP-value
1800 (50%)< 0.768< 0.0002> 0.979> 0.758
21200 (75%)< 0.806< 0.0002> 0.931> 0.216
Final1600 (100%)< 0.906< 0.0500  
  1. Adapted from Pocock et al. [195]; primary outcome events are cardiovascular deaths, myocardial infarction, or ischaemic stroke