Table 3 Exclusion criteria for the donor
1 Exclusion criteria related to general safety | |
Personal status | Â |
General | ➢ Presence of chronic disease ➢ Pregnant or lactating women ➢ Adults under guardianship, safeguard justice, or trusteeship ➢ For donors over the age of 50 years, absence of screening test for colorectal cancer within 2 years and positive test result |
Digestive | ➢ Celiac disease ➢ Irritable bowel syndrome ➢ Chronic constipation ➢ Diarrhea defined as > 3 very soft or liquid stools per day ➢ Hemorrhoids or rectal bleeding ➢ Personal history of: • gastrointestinal neoplasia or polyps • autoimmune or inflammatory disease • IBD |
Diet and drug use | ➢ Particular diet (exclusion diet, vegetarian diet) or other specific considerations: ingestion of a potential allergen (e.g. peanut) to which the recipient has a known allergy ➢  → Alcohol or drug abuse ➢ Spouse of a patient with IBD |
Family status | ➢ First-degree family history of: • IBD • gastrointestinal neoplasia or polyps before the age of 60 years • autoimmune or inflammatory disease ➢ Diarrhea defined as > 3 very soft or liquid stools per day for the family members within 3 months. |
2 Exclusion criteria related to prior or concomitant treatment | |
|  | ➢ No medication whatsoever in the 48 h before the donation (except contraceptive treatment) ➢ No regular curative medication except oral contraception ➢ Immunosuppressants (e.g. calcineurin inhibitors, corticosteroids, biological agents, etc.) antineoplastic chemotherapy ➢ Antibiotic or antifungal in the previous 3 months before the donation ➢ Non-steroidal anti-inflammatory intake in the previous month for the donation |
3 Exclusion criteria related to infection risk | |
General | ➢ Abnormal macroscopic appearance of stool ➢ Known infection by HIV, HTLV virus, hepatitis B or C virus ➢ Positive result in one of the contagious disease testing (see Appendix ANSM) ➢ Existence of anal lesions suggestive of viral infection (papillomas, vesicles, or other lesions) ➢ Multiresistant bacteria carrier (see Appendix ANSM) ➢ Risk of Creutzfeldt–Jakob disease ➢ Personal history of typhoid fever |
2 years | ➢ Residence in the intertropical zone > 2 years |
12 months | ➢ Hospitalization abroad > 24 h in the last 12 months (including members of the family) |
6 months | ➢ Contact with human blood (blood transfusion, piercing, tattoo, etc.) within the previous 6 months ➢ Sexual behavior risk (defined as unprotected sexual contact with a new partner) in the previous 6 months |
3 months | ➢ Gastroenteritis in the last 3 months Digestive disorders such as acute or chronic diarrhea in the 3 months preceding the donation ➢ Behavior deemed at risk of infection: travel in the previous 3 months |
14 days | ➢ Infectious episode 14 days before screening |
Blood tests | |
Biology | ➢ Abnormal local lab value concerning the following tests: fasting glucose, blood count, platelets, ferritin, CRP, ionogram, urea, creatinine, AST/ALT, gamma glutamyl transferase, alkaline phosphatase, bilirubin, prothrombin time, activated partial thromboplastin time, lipids (cholesterol, triglycerides) |
Virology, bacteriology, and parasitology | See Table 2 |
Stool test | |
Virology, bacteriology, and parasitology | See Table 2 |