Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients: protocol for a randomised, multicentre, open-label, superiority clinical trial (BEATLE)

Table 3 Sampling time in the study group (β-lactam antibiotic administration by extended infusion (EI)) according to the frequency of administration. Time expressed in minutes from the start of drug administration

	Frequency of administration	C_min	C_max (C₅₀₎	C_{max + 30}	C_{max + 60}	C₇₅
EI	6h	-10	180	210	240	270
	8h	-10	240	270	300	360
	12h	-10	360	390	420	540

ISSN: 1745-6215