Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients: protocol for a randomised, multicentre, open-label, superiority clinical trial (BEATLE)

Table 1 β-lactam antibiotic adjustment in renal impairment

β-lactam antibiotic	Creatinine clearance (mL/min)	Dose	Frequency
Piperacillin-tazobactam	30-40	4 g/0.5 g	Every 8 hours
Cefepime	30-50	2 g	Every 12 hours
Meropenem	30-50	1 g	Every 12 hours

ISSN: 1745-6215