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Table 1 Example trial scenarios

From: Managing clustering effects and learning effects in the design and analysis of multicentre randomised trials: a survey to establish current practice

Scenarios

A

A trial with a largea sample size, recruiting in several centres, each with multiple treatment providers

B

A trial with a smallb sample size, recruiting in several centres, each with multiple treatment providers

C

A trial that recruits within several centres, where treatment providers treat patients across recruiting centres; i.e. treatment provider is not unique to a centre

D

A trial recruiting from several centres, each with multiple treatment providers, investigating a surgical intervention

E

A trial recruiting from several centres, each with multiple treatment providers, investigating substantially different surgical interventions, e.g. a trial comparing surgery to an injection

  1. aCentres recruiting at least 10 patients per site
  2. bCentres recruiting 2 to 3 patients per site
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Trials

ISSN: 1745-6215