Fig. 1

Schedule of enrollment, interventions, and assessments. ^aBaseline variables: age; sex; etiology and duration of chronic pancreatitis (CP); history of acute pancreatitis; current alcohol and smoking status; complications of CP, including exocrine pancreatic insuficiency (EPI) and diabetes mellitus; cross-sectional imaging results; medications, including analgesics; and past history of endoscopic and/or surgical treatment. ^bPrimary outcome: Pain scores documented in a weekly pain diary based on a 0–10 visual analogue scale. ^cSecondary outcomes: Pain scores after 6 months, > 30% pain relief, number of pain-free days, analgesic consumption, frequency of hospitalizations, quality of life (European Organization for Research and Treatment of Cancer Quality of Life questionnaire), pain and physical functioning composite scores (modified Brief Pain Inventory–short form), anxiety and depression scores, patient global impression of change, and complications. ^dQuantitative sensory testing assessment parameters. ERCP Endoscopic retrograde cholangiopancreatography, ESWL Extracorporeal shock wave lithotripsy