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Table 3 Protocol glucocorticoid dose-tapering regimens for patients given prednisone during the first 10 weeks (of each study stage) for a skin vasculitis flare

From: Protocol for a randomized multicenter study for isolated skin vasculitis (ARAMIS) comparing the efficacy of three drugs: azathioprine, colchicine, and dapsone

Time from initiationDaily dose Option 1Daily dose Option 2
Days 1–330 mg/day10 mg/day
Days 4–620 mg/day7.5 mg/day
Days 7–915 mg/day5 mg/day
Days 10–1210 mg/day2.5 mg/day
Days 13–155 mg/day0
Days 16–182.5 mg/day0
Day 1900
  1. At week 12 (Stages 1 and 2), all patients must be off prednisone
  2. For patients requiring a second course of prednisone for vasculitis flare, the study drug will be considered a treatment failure