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Table 2 Modified CARG Risk score determination for treatment stratification (modified from Hurria et al. JCO 2011)

From: Durvalumab in frail and elderly patients with stage four non-small cell lung cancer: Study protocol of the randomized phase II DURATION trial

Toxicity factor/question

Value/response

Score

Age ≥ 72 years

≥ 72

2

Hemoglobin

< 11 g / dL (male)

< 10 g/dL (female)

3

Creatinine clearance

< 34 mL/min

3

Hearing

Fair/worse

2

Number of falls in the past 6 months

1 or more

3

Taking medications

With some help or unable

1

Walking 1 block (100 m)

Somewhat limited or limited a lot

2

Decreased social activity because of physical/emotional health

Limited at least sometimes

1