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Table 2 Modified CARG Risk score determination for treatment stratification (modified from Hurria et al. JCO 2011)

From: Durvalumab in frail and elderly patients with stage four non-small cell lung cancer: Study protocol of the randomized phase II DURATION trial

Toxicity factor/question Value/response Score
Age ≥ 72 years ≥ 72 2
Hemoglobin < 11 g / dL (male)
< 10 g/dL (female)
3
Creatinine clearance < 34 mL/min 3
Hearing Fair/worse 2
Number of falls in the past 6 months 1 or more 3
Taking medications With some help or unable 1
Walking 1 block (100 m) Somewhat limited or limited a lot 2
Decreased social activity because of physical/emotional health Limited at least sometimes 1