From: Does asymmetry in patient recruitment in large critical care trials follow the Pareto principle?
SAFE | NICE-SUGAR | RENAL | CHEST | ADRENAL | |
---|---|---|---|---|---|
Full Title | A comparison of albumin and saline for fluid resuscitation in the intensive care unit | Intensive versus conventional glucose control in critically ill patients | Intensity of continuous renal-replacement therapy in critically ill patients | Hydroxyethyl starch or saline for fluid resuscitation in intensive care | Adjunctive glucocorticoid therapy in patients with septic shock |
Recruitment period | November 2001 to June 2003 | December 2004 to November 2008 | December 2005 to August 2008 | December 2009 to January 2012 | March 2013 to April 2017 |
Number of patients | 7000 | 6104 | 1508 | 7000 | 3800 |
Number of participating ICUs | 16 | 42 | 35 | 32 | 69 |
Tertiary ANZa ICUs n (%) | 13 (81) | 15 (36) | 22 (63) | 16 (50) | 24 (35) |
Non-tertiary ANZ ICUs n (%) | 3 (19) | 10 (24) | 13 (37) | 16 (50) | 29 (42) |
Non-ANZ ICUs n (%) | 0 (0) | 17 (40) | 0 (0) | 0 (0) | 16 (23) |
Number of patients recruited in tertiary ANZ ICUs n (%) | 5917 (85) | 4118 (67) | 1179 (78) | 5246 (75) | 1859 (49) |
Number of patients recruited in non-tertiary ANZ ICUs n (%) | 1083 (15) | 1230 (20) | 329 (22) | 1754 (25) | 1280 (34) |
Number of patients recruited in non-ANZ ICUs n (%) | 0 (0) | 756 (12) | 0 (0) | 0 (0) | 661 (17) |
Months of recruitment | 18.8 | 44.4 | 32.1 | 25.2 | 58.3 |
Peak daily recruitment rate | 18.42 | 5.65 | 2.36 | 14.89 | 3.3 |
Peak monthly recruitment rate | 560.3 | 171.9 | 71.8 | 452.9 | 100.4 |
Average daily recruitment rate | 12.26 | 4.52 | 1.55 | 9.11 | 2.14 |
Average monthly recruitment rate | 372.9 | 137.5 | 47.1 | 277.1 | 65.1 |
Number of concomitant ANZICSb CTGc trials | 0 | 4 | 4 | 9 | 13 |
Total patients recruited per site (Mean (SD)) | 438 (130.7) | 145 (155.5) | 43 (44.9) | 219 (192.1) | 55 (48.6) |
Median (IQR) | 444 (330–524) | 97 (40–221) | 29 (19–46) | 156 (75–315) | 22 (38–72) |
Range | 225–656 | 3–647 | 6–180 | 2–767 | 3–264 |
Monthly recruitment per site (Mean (SD)) | 28.9 (6.96) | 4.5 (3.6) | 1.7 (1.6) | 11.4 (9) | 1.4 (1) |
Median (IQR) | 28 (23–35) | 3.4 (1.6–5.7) | 1.4 (0.8–1.8) | 8.8 (4.5–16) | 1 (0.7–1.8) |
Range | 18–41 | 0.7–17 | 0.4–6.8 | 0.3–31 | 0.1–5 |