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Table 1 This is a table showing characteristics of each trial including recruitment period, participating sites and average recruitment rates

From: Does asymmetry in patient recruitment in large critical care trials follow the Pareto principle?

 

SAFE

NICE-SUGAR

RENAL

CHEST

ADRENAL

Full Title

A comparison of albumin and saline for fluid resuscitation in the intensive care unit

Intensive versus conventional glucose control in critically ill patients

Intensity of continuous renal-replacement therapy in critically ill patients

Hydroxyethyl starch or saline for fluid resuscitation in intensive care

Adjunctive glucocorticoid therapy in patients with septic shock

Recruitment period

November 2001 to June 2003

December 2004 to November 2008

December 2005 to August 2008

December 2009 to January 2012

March 2013 to April 2017

Number of patients

7000

6104

1508

7000

3800

Number of participating ICUs

16

42

35

32

69

Tertiary ANZa ICUs n (%)

13 (81)

15 (36)

22 (63)

16 (50)

24 (35)

Non-tertiary ANZ ICUs n (%)

3 (19)

10 (24)

13 (37)

16 (50)

29 (42)

Non-ANZ ICUs n (%)

0 (0)

17 (40)

0 (0)

0 (0)

16 (23)

Number of patients recruited in tertiary ANZ ICUs n (%)

5917 (85)

4118 (67)

1179 (78)

5246 (75)

1859 (49)

Number of patients recruited in non-tertiary ANZ ICUs n (%)

1083 (15)

1230 (20)

329 (22)

1754 (25)

1280 (34)

Number of patients recruited in non-ANZ ICUs n (%)

0 (0)

756 (12)

0 (0)

0 (0)

661 (17)

Months of recruitment

18.8

44.4

32.1

25.2

58.3

Peak daily recruitment rate

18.42

5.65

2.36

14.89

3.3

Peak monthly recruitment rate

560.3

171.9

71.8

452.9

100.4

Average daily recruitment rate

12.26

4.52

1.55

9.11

2.14

Average monthly recruitment rate

372.9

137.5

47.1

277.1

65.1

Number of concomitant ANZICSb CTGc trials

0

4

4

9

13

Total patients recruited per site (Mean (SD))

438 (130.7)

145 (155.5)

43 (44.9)

219 (192.1)

55 (48.6)

Median (IQR)

444 (330–524)

97 (40–221)

29 (19–46)

156 (75–315)

22 (38–72)

Range

225–656

3–647

6–180

2–767

3–264

Monthly recruitment per site (Mean (SD))

28.9 (6.96)

4.5 (3.6)

1.7 (1.6)

11.4 (9)

1.4 (1)

Median (IQR)

28 (23–35)

3.4 (1.6–5.7)

1.4 (0.8–1.8)

8.8 (4.5–16)

1 (0.7–1.8)

Range

18–41

0.7–17

0.4–6.8

0.3–31

0.1–5

  1. a ANZ- Australia and New Zealand
  2. b ANZICS- Australia New Zealand Intensive Care Society
  3. c CTG- Clinical Trials Group