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Table 1 Definitions of combined endpoints

From: Hypotheses, rationale, design, and methods for prognostic evaluation of a randomized comparison between patients with coronary artery disease associated with ischemic cardiomyopathy who undergo medical or surgical treatment: MASS-VI (HF)

Mortality from any cause Mortality from any cause is included as a composite primary event. Cardiovascular death includes that from myocardial infarction, sudden death, refractory heart failure, fatal hemorrhagic cerebral infarction or fatal cerebral hemorrhage related to the procedure.
Vascular brain accident Patients with focal neurological deficit of central origin lasting more than 72 h or a focal neurological deficit of central origin that lasted more than 24 h, with evidence of images of cerebral infarction or intracerebral hemorrhage, or non-focal encephalopathy that lasted more than 24 h, with evidence of images of cerebral infarction or bleeding sufficient to warrant clinical status. Retinal arterial ischemia or bleeding is also included. To meet the definitions of stroke, the deficit must be new or sudden—consensually—not attributable to any alternative.
Acute myocardial infarction Elevation of specific cardiac enzymes within 14 days of the revascularization procedure and the presence of new Q waves in at least two or more contiguous ECG leads, and elevation of 10x the 99th percentile of CK-MB and ultrasensitive troponin.
Additional revascularization Initial revascularization is considered complete when the patient is transferred from the operating room to the ward. Refractory angina requiring additional revascularization is considered an event.