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Table 1 Sample size per arm necessary for a two-arm trial, for a fixed delta of 10 percentage points, a margin d of 2.5 or 5 percentage points, and Pmost at 80% or 85%. The tumour response rate with drug A varies between 20 and 80%

From: Sample size calculation in randomised phase II selection trials using a margin of practical equivalence

 Margin d 2.5%Margin d 5%
TRR drug ATRR drug BPmost 80%Pmost  85%Pmost  80%Pmost 85%
20%10%19281935
30%20%27463254
40%30%33533759
50%40%36573973
60%50%36573973
70%60%33533770
80%70%27463254