Table 1 Sample size per arm necessary for a two-arm trial, for a fixed delta of 10 percentage points, a margin d of 2.5 or 5 percentage points, and Pmost at 80% or 85%. The tumour response rate with drug A varies between 20 and 80%
Margin d 2.5% | Margin d 5% | ||||
|---|---|---|---|---|---|
TRR drug A | TRR drug B | Pmost 80% | Pmost 85% | Pmost 80% | Pmost 85% |
20% | 10% | 19 | 28 | 19 | 35 |
30% | 20% | 27 | 46 | 32 | 54 |
40% | 30% | 33 | 53 | 37 | 59 |
50% | 40% | 36 | 57 | 39 | 73 |
60% | 50% | 36 | 57 | 39 | 73 |
70% | 60% | 33 | 53 | 37 | 70 |
80% | 70% | 27 | 46 | 32 | 54 |