| Intervention Development | 1. Using theory in behavioral intervention development |
| 2. Use of systematic approaches to move from evidence to intervention components |
| 3. Specifying intervention components |
| 4. Exploring impact of mode of intervention delivery |
| 5. Tailoring interventions to specific populations and contexts |
| Comparison Group | 6. Selection of suitable comparison group(s) within trials |
| 7. Contamination between study arms (intervention and comparison) within trials |
| 8. Blinding of researchers and participants to study-arm allocation |
| Intervention Fidelity | 9. Impact on intervention delivery of characteristics (such as qualifications and training) of those delivering interventions |
| 10. Strategies to optimize intervention fidelity |
| 11. Methods to assess intervention fidelity |
| 12. Strategies to maximize trial participant recruitment and retention |
| Pilot/Feasibility trials | 13. Establishing criteria for progressing from trial piloting phases to full randomized controlled trial (RCT) |
| 14. Sample-size calculations for pilot trials |
| 15. Novel approaches and designs for piloting behavioral interventions |
| Reporting | 16. Standardizing methods for reporting behavioral trials |
| 17. Reporting intervention and comparison group(s) intervention content |
| 18. Standardized methods for reporting and registering behavioral trials’ protocols |
| Novel Trial Designs | 19. Development of novel research designs to test behavioral interventions as alternatives to, or to complement, standard RCTs |
| Data Issues | 20. Strategies for handling missing data within behavioral trials |
| 21. Developing novel statistical techniques to enhance behavioral trials |
| Outcomes | 22. Determining clinically significant changes in outcomes within trials |
| 23. Selecting appropriate behavioral outcomes for trials |
| 24. Relationship between behavioral outcomes and clinical/other outcomes |
| 25. Determining ideal timing of outcome measurement within trials |
| 26. Measurement of process(es) of change or mechanisms of action within interventions |
| Cost-effectiveness | 27. Methods for cost-effectiveness analyses for behavioral trials |
| Implementation | 28. Methods for ensuring that behavioral interventions are implementable into practice and policy |
| 29. How to disseminate behavioral trial research findings to increase implementation |
| Stakeholder engagement | 30. How to optimize stakeholder engagement in behavioral trial research |
| 31. Incorporating stakeholder input in intervention development and delivery |
| 32. Testing the impact of stakeholder engagement in behavioral trial research |
| Development of behavioral science and theory | 33. Trials’ research to test and develop behavioral theories |
