Fig. 2

Virtual execution of Bayesian designs B1-B3 using the PARAMEDIC2 data. a) Bayesian design B1, b) Bayesian design B2; c) Bayesian design B3. The posterior probability of having adrenaline superior at each analysis is displayed as an open circle. The posterior probability of having placebo superior is 1 – the probability adrenaline is superior. The stopping boundaries for adrenaline superior are given as the black solid line with open squares; the stopping boundaries for placebo superior/adrenaline harmful are given as the green dotted line with closed triangles. The x-axis displays the analysis number and so the number of patients at each analysis generally differs between the designs